Genomic Engineering Group / InteLAB
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Thursday, 22 February 2018
Chorioallantoic Membrane Assays PDF Print

Development and production of films and polymeric matrices (scaffolds) are widely studied for several biomedical applications. The incorporation of drugs into those polymers so they can properly be delivered is now the subject of several research groups.

Inhibition of blood vessel vascularization is an important strategy to fight tumors. Anti-angiogenic therapy developments will rely on our capacity to test and evaluate drug efficiency against tumor growth. The temporal and spatial drug concentration profiles should to be known to assist in the dosage and frequency of drug administration. Implanted animal tumor models and other animal models should be avoided when other techniques are available. Chorioallantoic membrane assays are been used in our labs to evaluate anti-angiogenic effects of aloin (a compound extrated from the plant Aloe vera) when combined with biopolymers, but the intrinsic dynamics of the embrio and the vascularization make the system very difficult to work with. On the other hand, chorioallantoic membranes are readily available, they are cheap, and respond very quick.  We are now investigating new ways to circumvent the difficulties presented by the membranes so they can be used to collect in vivo parameters for anti-angiogenic therapy designs.

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