Genomic Engineering Group / InteLAB
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Saturday, 23 September 2017
Diffusion in Tissues PDF Print

The problem of designing suitable biodegradable (bio)polymers as drug-eluting media is very dependent on the physicochemical properties of the drug such as its hydrophilicity as well as the polymer, and its interactions with the drug and the environment. Variations in pH, osmotic pressure and tissue replacement are some of the variables that will need to be considered.

Computational fluid dynamics (CFD) techniques are now been used in several tissue engineering evaluations (for instance, to evaluate drug-eluting stents). The challenge is to reproduce in the model, either mathematical or in vitro, the in vivo conditions which certainly vary according to the patient’s response. Enzyme degradation of bioerodible polymeric systems, for example, is supposed to be faster in vivo due to enzymatic reactions. Enzyme levels and activities, on the other hand, should be expected to depend on the local tissue properties, not to mention nucleotide variations (haplotypes) among individuals.

Genomic engineering will play an important role in future developments of advanced drug-eluting systems and their dynamic performance. Advanced model systems will take into account the kinetics and thermodynamics of drug-matrix, drug-cell receptor, and drug-microenvironment interactions, as well as the reshaping of target tissue and scaffolds. An important bottleneck is the availability of in vivo parameters. Therefore, much work has to be done to develop physical and conceptual models that could be used to quantify biological and physicochemical properties.

 
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