Genomic Engineering Group / InteLAB
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Thursday, 22 February 2018
Violacein PDF Print

Violacein, BRN 0049923 ...

IUPAC: (3Z)-3-[5-(5-hydroxy-1H-indol-3-yl)-2-oxo-1H-pyrrol-3-ylidene]-1H-indol-2-one

MW: 343.336 | MF: C20H13N3O3


Violacein (CID: 5359453) is a purple pigment produced by violet-pigmented bacteria, particularly by the genus Chromobacterium. We have been using Chromobacterium violaceum as a model organism in our laboratories, for several reasons, among them to better understand bacterial intercellular communication (quorum sensing) and its possible symmetries with general cell communication systems in cell colonies and tissues.

Violacein has been reported to have a diverse spectrum of biological activities, particularly as a cytotoxic drug, being cited as having antitumoral (antileukemic) and anti-Trypanosome cruzi (anti-Chagas desease), among several other medical and pharmacological properties.

Violacein per se is a very interesting molecule. It is made up of two “condensed” tryptophan molecules, by the action of a handful of genes clustered as an operon.

We are currently investigated violacein bioactivity in cell cultures, when combined with biopolymeric scaffolds.

We are also interested in how violacein biosynthesis is regulated and the expression of violacein-related genes in E. coli.

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