Genomic Engineering Group / InteLAB
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Friday, 24 November 2017
Aloin PDF Print

Aloin (CID: 313325), also known as barbaloin, is a biological active anthraquinone extracted from Aloe vera, a very popular industrial crop. A. vera is known for its therapeutic and pharmacological properties, which include antitumor, antidiabetic, and antityrosinase, in additionn to act in healing wounds and burns, and treatment of gastric ulcers.

It is reported that aloin stabilizes lamellar structures and promotes the formation of gel–fluid intermediate structures in phosphatidylglycerol membranes at physiological pH and ionic strength values.

Although aloin itself is a potential pharmaceutical product, orally administered baloin is poorly absorbed and is metabolized by intestinal microflora to aloe emodin. It is also well known that oral administration may not be well tolerated by most people in small even in small doses.

We are particular interested in combining aloin with 2-D and 3-D biopolymer templates produced by bacteria, particularly PHA and bacterial cellulose scaffolds as an efficient way to deliver aloin locally.

IUPAC: 1,8-dihydroxy-3-(hydroxymethyl)-10-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-10H-anthracen-9-one

MW: 418.394 | MF: C21H22O9
 
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