Genomic Engineering Group / InteLAB
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Wednesday, 28 June 2017
Bioinformatics

Bioinformatics and computational biology present a set of tools and techniques useful to solve biologial problems usually on the molecular level. Post-genome bioinformatics makes extensive use of genomic information (from sequenced genomes), mostly to compare two or more sequences (of nucleotides or amino acids), in order to find similarities and differences. Based on such comparisons, homologies may be assigned, and functional correlations may be attributed.It is a bioinformatics dogma that sequence correlations are associated with functional correlations. More interesting, structural similarities are usually associated with functional properties, thus providing evidence of biological activity.In our group we extensively use comparative genomics to study regulatory proteins and enzyme functions. In particular, we are interested in transcription factor binding sites (located in non-coding regions of the DNA) and polymerization sites of bacterial enzymes. Other tools have been used to characterize full metabolic (genome-wide) pathways and to find gene structure (operons and regulations).

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Comparative Genomics
Genes and Operons Organization
Chromobacterium violaceum Pathway-Genome Database
 
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